購(gòu)物車
幫助
021-54845833/15800441009
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Background: |
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome. [provided by RefSeq]. |
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Applications: |
WB, IHC, FC |
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Name of antibody: |
PSMA6 |
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Immunogen: |
Fusion protein of human PSMA6 |
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Full name: |
proteasome (prosome, macropain) subunit, alpha type, 6 (PSMA6), transcript variant 1 |
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Synonyms: |
IOTA; p27K; PROS27 |
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SwissProt: |
P60900 |
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IHC positive control: |
carcinoma of human lung tissue and adenocarcinoma of human ovary tissue; carcinoma of human bladder tissue and carcinoma of human prostate tissue |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
27 kDa |
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WB Positive control: |
HepG2, Hela, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF-7 cell lysates |
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WB Recommended dilution: |
500-2000 |
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