購(gòu)物車
幫助
021-54845833/15800441009
|
Background: |
P23, also known as PTGES3 (prostaglandin E synthase 3) or TEBP (telomerase-binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. One of several proteins in the HSP 90-based molecular chaperone complex, P23 promotes the breakdown of transcriptional regulatory complexes by disrupting receptor-mediated transcriptional activation. P23 acts in a hormone-dependent manner to chaperone estrogen receptor alpha (ER ), a steroid complex, to its mature form and to regulate the expression of ER -related genes. Localized to the cytoplasm, P23 interacts with the glucocorticoid receptor (GR) and, through disassembly of the GR transcription machinery, is thought to inhibit GR-dependent transcription. The involvement of P23 in various steroid receptor-mediated pathways suggests close involvement in signal transduction and regulation of cellular processes. Upregulation of P23 is implicated in the invasion and metastasis of various cancers. |
|
Applications: |
WB, IHC |
|
Name of antibody: |
PTGES3 |
|
Immunogen: |
Fusion protein of human PTGES3 |
|
Full name: |
prostaglandin E synthase 3 (cytosolic) (PTGES3), transcript variant 1 |
|
Synonyms: |
cPGES; P23; TEBP |
|
SwissProt: |
Q15185 |
|
IHC positive control: |
adenocarcinoma of human ovary tissue |
|
IHC Recommend dilution: |
30-150 |
|
WB Predicted band size: |
19 kDa |
|
WB Positive control: |
A549 cell lysate |
|
WB Recommended dilution: |
500-2000 |
- 首頁(yè)
- 科研產(chǎn)品
ELISA試劑盒
PCR試劑盒
生化試劑盒
細(xì)胞系
細(xì)胞庫(kù)
基礎(chǔ)培養(yǎng)基
完全培養(yǎng)基
原代細(xì)胞
細(xì)胞專用培養(yǎng)基
菌株
生化試劑
病理染色液
科研抗體
標(biāo)準(zhǔn)品
血清
- 公司簡(jiǎn)介
- 公司新聞
- 技術(shù)服務(wù)
- 代理品牌
- 訂購(gòu)中心
- 加入通蔚
