購物車
幫助
021-54845833/15800441009
|
Full name: |
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 |
|
Synonyms: |
S2; P97; Rpn1; TRAP2 |
|
Swissprot: |
Q13200 |
|
Gene Accession: |
BC007897 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. |
- 首頁
- 科研產(chǎn)品
ELISA試劑盒
PCR試劑盒
生化試劑盒
細胞系
細胞庫
基礎(chǔ)培養(yǎng)基
完全培養(yǎng)基
原代細胞
細胞專用培養(yǎng)基
菌株
生化試劑
病理染色液
科研抗體
標準品
血清
- 公司簡介
- 公司新聞
- 技術(shù)服務(wù)
- 代理品牌
- 訂購中心
- 加入通蔚
