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021-54845833/15800441009
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Full name: |
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase |
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Synonyms: |
RSP5; NEDD4-2; NEDD4.2; hNEDD4-2 |
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Swissprot: |
Q96PU5 |
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Gene Accession: |
BC032597 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. |
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