購物車
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021-54845833/15800441009
中文名稱： 兔抗MCM4多克隆抗體
英文名稱： Anti-MCM4 rabbit polyclonal antibody
別 名： CDC21, CDC54, hCdc21, P1-CDC21
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： MCM4
反應(yīng)種屬： Human, Mouse
標 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
MCM4 |
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Immunogen: |
Synthetic peptide of human MCM4 |
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Full name: |
Minichromosome maintenance complex component 4 |
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Synonyms： |
CDC21, CDC54, hCdc21, P1-CDC21 |
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SwissProt: |
P33991 |
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ELISA Recommended dilution: |
1000-5000 |
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IHC positive control: |
Human brain and Human breast cancer |
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IHC Recommend dilution: |
50-200 |
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WB Predicted band size: |
97 kDa |
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WB Positive control: |
NIH/3T3, Hela and K562 cells |
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WB Recommended dilution: |
500-2000 |
