購(gòu)物車
幫助
021-54845833/15800441009
中文名稱： 兔抗NR2F6多克隆抗體
英文名稱： Anti-NR2F6 rabbit polyclonal antibody
別 名： EAR2; EAR-2; ERBAL2
相關(guān)類別： 一抗
抗 原： NR2F6
儲(chǔ) 存： 冷凍（-20℃） 避光
宿 主： Rabbit
反應(yīng)種屬： Human Mouse Rat
標(biāo) 記 物： Unconjugate
克隆類型： Unconjugate
技術(shù)規(guī)格
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Background: |
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). |
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Applications: |
WB, IHC, IF |
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Name of antibody: |
NR2F6 |
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Immunogen: |
Synthesized peptide derived from N-terminal of human NR2F6. |
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Full name: |
nuclear receptor subfamily 2, group F, member 6 |
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Synonyms： |
EAR2; EAR-2; ERBAL2 |
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SwissProt: |
P10588 |
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IHC positive control: |
Human cervix carcinoma tissue |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
43 kDa |
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WB Positive control: |
Hela cells, 293 cells and Huvec cells lysates |
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WB Recommended dilution: |
500-3000 |
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IF positive control: |
HepG2 cells |
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IF Recommend dilution: |
100-500 |
