購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)： CDK2AP1抗原（重組蛋白）
|
Full name: |
cyclin dependent kinase 2 associated protein 1 |
|
Synonyms: |
DOC1; ST19; DORC1; doc-1; p12DOC-1 |
|
Swissprot: |
O14519 |
|
Gene Accession: |
BC034717 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
